Role of κ→λ light-chain constant-domain switch in the structure and functionality of A17 reactibody

The engineering of catalytic function in antibodies requires precise information on their structure. Here, results are presented that show how the antibody domain structure affects its functionality. The previously designed organophos­phate-metabolizing reactibody A17 has been re-engineered by repla...

Descripción completa

Detalles Bibliográficos
Autores principales: Ponomarenko, Natalia, Chatziefthimiou, Spyros D., Kurkova, Inna, Mokrushina, Yuliana, Stepanova, Anastasiya, Smirnov, Ivan, Avakyan, Marat, Bobik, Tatyana, Mamedov, Azad, Mitkevich, Vladimir, Belogurov, Alexey, Fedorova, Olga S., Dubina, Michael, Golovin, Andrey, Lamzin, Victor, Friboulet, Alain, Makarov, Alexander A., Wilmanns, Matthias, Gabibov, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2014
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949517/
https://www.ncbi.nlm.nih.gov/pubmed/24598740
http://dx.doi.org/10.1107/S1399004713032446

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949517/
https://www.ncbi.nlm.nih.gov/pubmed/24598740
http://dx.doi.org/10.1107/S1399004713032446

Ejemplares similares