Cargando…
Neuronal activity regulates extracellular tau in vivo
Tau is primarily a cytoplasmic protein that stabilizes microtubules. However, it is also found in the extracellular space of the brain at appreciable concentrations. Although its presence there may be relevant to the intercellular spread of tau pathology, the cellular mechanisms regulating tau relea...
Autores principales: | Yamada, Kaoru, Holth, Jerrah K., Liao, Fan, Stewart, Floy R., Mahan, Thomas E., Jiang, Hong, Cirrito, John R., Patel, Tirth K., Hochgräfe, Katja, Mandelkow, Eva-Maria, Holtzman, David M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949564/ https://www.ncbi.nlm.nih.gov/pubmed/24534188 http://dx.doi.org/10.1084/jem.20131685 |
Ejemplares similares
-
Analysis of in vivo turnover of tau in a mouse model of tauopathy
por: Yamada, Kaoru, et al.
Publicado: (2015) -
Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease
por: Roh, Jee Hoon, et al.
Publicado: (2014) -
Sleep in Alzheimer's Disease–Beyond Amyloid
por: Holth, Jerrah K., et al.
Publicado: (2016) -
Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration
por: Ishida, Kazuhisa, et al.
Publicado: (2022) -
Altered sleep and EEG power in the P301S Tau transgenic mouse model
por: Holth, Jerrah K., et al.
Publicado: (2017)