Blimp-1 represses CD8 T cell expression of PD-1 using a feed-forward transcriptional circuit during acute viral infection

Programmed cell death 1 (PD-1) is an inhibitory immune receptor that regulates T cell function, yet the molecular events that control its expression are largely unknown. We show here that B lymphocyte–induced maturation protein 1 (Blimp-1)–deficient CD8 T cells fail to repress PD-1 during the early...

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Detalles Bibliográficos
Autores principales: Lu, Peiyuan, Youngblood, Benjamin A., Austin, James W., Rasheed Mohammed, Ata Ur, Butler, Royce, Ahmed, Rafi, Boss, Jeremy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949569/
https://www.ncbi.nlm.nih.gov/pubmed/24590765
http://dx.doi.org/10.1084/jem.20130208

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949569/
https://www.ncbi.nlm.nih.gov/pubmed/24590765
http://dx.doi.org/10.1084/jem.20130208

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