Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells

A proper balance between Th17 and T regulatory cells (T(reg) cells) is critical for generating protective immune responses while minimizing autoimmunity. We show that the Tec family kinase Itk (IL2-inducible T cell kinase), a component of T cell receptor (TCR) signaling pathways, influences this bal...

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Detalles Bibliográficos
Autores principales: Gomez-Rodriguez, Julio, Wohlfert, Elizabeth A., Handon, Robin, Meylan, Françoise, Wu, Julie Z., Anderson, Stacie M., Kirby, Martha R., Belkaid, Yasmine, Schwartzberg, Pamela L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949578/
https://www.ncbi.nlm.nih.gov/pubmed/24534190
http://dx.doi.org/10.1084/jem.20131459

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949578/
https://www.ncbi.nlm.nih.gov/pubmed/24534190
http://dx.doi.org/10.1084/jem.20131459

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