Macrocyclic Pyridyl Polyoxazoles: Structure-Activity Studies of the Aminoalkyl Side-Chain on G-Quadruplex Stabilization and Cytotoxic Activity

Pyridyl polyoxazoles are 24-membered macrocyclic lactams comprised of a pyridine, four oxazoles and a phenyl ring. A derivative having a 2-(dimethylamino)ethyl chain attached to the 5-position of the phenyl ring was recently identified as a selective G-quadruplex stabilizer with excellent cytotoxic...

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Detalles Bibliográficos
Autores principales: Blankson, Gifty, Rzuczek, Suzanne G., Bishop, Cody, Pilch, Daniel S., Liu, Angela, Liu, Leroy, LaVoie, Edmond J., Rice, Joseph E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949622/
https://www.ncbi.nlm.nih.gov/pubmed/24077174
http://dx.doi.org/10.3390/molecules181011938

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949622/
https://www.ncbi.nlm.nih.gov/pubmed/24077174
http://dx.doi.org/10.3390/molecules181011938

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