Cargando…

Macrocyclic Pyridyl Polyoxazoles: Structure-Activity Studies of the Aminoalkyl Side-Chain on G-Quadruplex Stabilization and Cytotoxic Activity

Pyridyl polyoxazoles are 24-membered macrocyclic lactams comprised of a pyridine, four oxazoles and a phenyl ring. A derivative having a 2-(dimethylamino)ethyl chain attached to the 5-position of the phenyl ring was recently identified as a selective G-quadruplex stabilizer with excellent cytotoxic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Blankson, Gifty, Rzuczek, Suzanne G., Bishop, Cody, Pilch, Daniel S., Liu, Angela, Liu, Leroy, LaVoie, Edmond J., Rice, Joseph E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949622/ https://www.ncbi.nlm.nih.gov/pubmed/24077174 http://dx.doi.org/10.3390/molecules181011938

Ejemplares similares

Defining the mode, energetics and specificity with which a macrocyclic hexaoxazole binds to human telomeric G-quadruplex DNA
por: Barbieri, Christopher M., et al.
Publicado: (2007)

Synthesis of Aminoalkyl Sclareolide Derivatives and Antifungal Activity Studies
por: Li, Ziyi, et al.
Publicado: (2023)

Synthesis and antimicrobial activity of aminoalkyl resveratrol derivatives inspired by cationic peptides
por: Cebrián, Rubén, et al.
Publicado: (2023)

Silver triflate catalyzed synthesis of 3-aminoalkylated indoles and evaluation of their antibacterial activities
por: Rao, Vagicherla Kameshwara, et al.
Publicado: (2011)

TXH11106: A Third-Generation MreB Inhibitor with Enhanced Activity against a Broad Range of Gram-Negative Bacterial Pathogens
por: Bryan, Eric J., et al.
Publicado: (2022)

Effective Activation by Kynurenic Acid and Its Aminoalkylated Derivatives on M-Type K(+) Current
por: Lo, Yi-Ching, et al.
Publicado: (2021)

Correction: Metal-free [2+2+1] cycloaddition polymerization of alkynes, nitriles, and oxygen atoms to functional polyoxazoles
por: Dong, Lichao, et al.
Publicado: (2021)

Retraction: Metal-free [2+2+1] cycloaddition polymerization of alkynes, nitriles, and oxygen atoms to functional polyoxazoles
por: Dong, Lichao, et al.
Publicado: (2021)

Electrochemical halogen-atom transfer alkylation via α-aminoalkyl radical activation of alkyl iodides
por: Sun, Xiang, et al.
Publicado: (2023)

Retracted Article: Metal-free [2+2+1] cycloaddition polymerization of alkynes, nitriles, and oxygen atoms to functional polyoxazoles
por: Dong, Lichao, et al.
Publicado: (2020)

Synthesis and Telomeric G-Quadruplex-Stabilizing Ability of Macrocyclic Hexaoxazoles Bearing Three Side Chains
por: Ma, Yue, et al.
Publicado: (2019)

Using Macrocyclic G‐Quadruplex Ligands to Decipher the Interactions Between Small Molecules and G‐Quadruplex DNA
por: Andréasson, Måns, et al.
Publicado: (2022)

Quantitative Structure–Activity Relationships of Natural-Product-Inspired, Aminoalkyl-Substituted 1-Benzopyrans as Novel Antiplasmodial Agents
por: Wunsch, Friederike M., et al.
Publicado: (2021)

Is there a special relationship between complex I activity and nigral neuronal loss in Parkinson’s disease? A critical reappraisal
por: Subrahmanian, Nitya, et al.
Publicado: (2021)

Macrocyclization of bis-indole quinolines for selective stabilization of G-quadruplex DNA structures
por: Das, Rabindra Nath, et al.
Publicado: (2020)

Similar Safety Profile of the Enantiomeric N-Aminoalkyl Derivatives of Trans-2-Aminocyclohexan-1-ol Demonstrating Anticonvulsant Activity
por: Słoczyńska, Karolina, et al.
Publicado: (2019)

Synthesis, Antibacterial and Antiribosomal Activity of the 3C-Aminoalkyl Modification in the Ribofuranosyl Ring of Apralogs (5-O-Ribofuranosyl Apramycins)
por: Lubriks, Dmitrijs, et al.
Publicado: (2022)

Photocatalytic enantioselective α-aminoalkylation of acyclic imine derivatives by a chiral copper catalyst
por: Han, Bowen, et al.
Publicado: (2019)

A case of chain propagation: α-aminoalkyl radicals as initiators for aryl radical chemistry
por: Constantin, Timothée, et al.
Publicado: (2020)

Cyclizations and fragmentations in the alkylation of 6‐chloro‐5‐hydroxy‐4‐aminopyrimidines with aminoalkyl chlorides
por: Picazo, Edwige M. H., et al.
Publicado: (2021)

Synthesis and biochemical evaluation of 17-N-beta-aminoalkyl-4,5α-epoxynormorphinans
por: Ötvös, Ferenc, et al.
Publicado: (2023)

2-[(3-Aminoalkyl-(alkaryl-,aryl-))-(1)H-1,2,4-triazol-5-yl]anilines: synthesis and anticonvulsant activity
por: MARTYNENKO, Yulya, et al.
Publicado: (2020)

Targeting glioma stem cells in vivo by a G-quadruplex-stabilizing synthetic macrocyclic hexaoxazole
por: Nakamura, Takahiro, et al.
Publicado: (2017)

Unexpected Reaction Pathway of the Alpha-Aminoalkyl Radical Derived from One-Electron Oxidation of S-Alkylglutathiones
por: Pedzinski, Tomasz, et al.
Publicado: (2020)

Lewis acid mediated, mild C–H aminoalkylation of azoles via three component coupling
por: Emmert, Marion H., et al.
Publicado: (2021)

Rapid assembly of structurally diverse cyanamides and disulfanes via base-mediated aminoalkylation of aryl thiourea
por: Zheng, Yongpeng, et al.
Publicado: (2023)

Tailoring the Spacer Arm for Covalent Immobilization of Candida antarctica Lipase B—Thermal Stabilization by Bisepoxide-Activated Aminoalkyl Resins in Continuous-Flow Reactors
por: Abaházi, Emese, et al.
Publicado: (2016)

Structure-Guided Design of a Fluorescent Probe for the Visualization of FtsZ in Clinically Important Gram-Positive and Gram-Negative Bacterial Pathogens
por: Ferrer-González, Edgar, et al.
Publicado: (2019)

A novel family of (1-aminoalkyl)(trifluoromethyl)- and -(difluoromethyl)phosphinic acids – analogues of α-amino acids
por: Pavlenko, Natalia V, et al.
Publicado: (2014)

Selective and clean synthesis of aminoalkyl-H-phosphinic acids from hypophosphorous acid by phospha-Mannich reaction
por: Urbanovský, Peter, et al.
Publicado: (2020)

Cobalt-catalyzed aminoalkylative carbonylation of alkenes toward direct synthesis of γ-amino acid derivatives and peptides
por: Wang, Le-Cheng, et al.
Publicado: (2023)

Antimicrobial Activity of Calixarenes and Related Macrocycles
por: Shurpik, Dmitriy N., et al.
Publicado: (2020)

“One Ring to Bind Them All”—Part I: The Efficiency of the Macrocyclic Scaffold for G-Quadruplex DNA Recognition
por: Monchaud, David, et al.
Publicado: (2010)

Copper‐Catalyzed Borylation of Cyclic Sulfamidates: Access to Enantiomerically Pure (β‐and γ‐Aminoalkyl)boronic Esters
por: Ursinyova, Nina, et al.
Publicado: (2015)

A Class of 4-Sulfamoylphenyl-ω-aminoalkyl Ethers with Effective Carbonic Anhydrase Inhibitory Action and Antiglaucoma Effects
por: Bozdag, Murat, et al.
Publicado: (2014)

O-Aminoalkyl-O-Trimethyl-2,3-Dehydrosilybins: Synthesis and In Vitro Effects Towards Prostate Cancer Cells
por: Vue, Bao, et al.
Publicado: (2018)

Multimodal switching of a redox-active macrocycle
por: Payne, Daniel T., et al.
Publicado: (2019)

Reductive Dimerization of Macrocycles Activated by BBr(3)
por: Kijewska, Monika, et al.
Publicado: (2021)

Phenyl Substituted 4-Hydroxypyridazin-3(2H)-ones and 5-Hydroxypyrimidin-4(3H)-ones: Inhibitors of Influenza A Endonuclease
por: Sagong, Hye Yeon, et al.
Publicado: (2014)

Evaluation of the Interaction between Long Telomeric DNA and Macrocyclic Hexaoxazole (6OTD) Dimer of a G-quadruplex Ligand
por: Iida, Keisuke, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_jjva7lon60juna8re3bplngtgc