Development of a Novel Severe Triple Allergen Asthma Model in Mice Which Is Resistant to Dexamethasone and Partially Resistant to TLR7 and TLR9 Agonist Treatment

Severe asthma is characterised by persistent inflammation, hyperreactivity and remodeling of the airways. No efficient treatment is available, this is particularly the case for steroid resistant phenotypes. Our aim therefore was to develop a preclinical model showing characteristics of severe human...

Descripción completa

Detalles Bibliográficos
Autores principales: Duechs, Matthias J., Tilp, Cornelia, Tomsic, Christopher, Gantner, Florian, Erb, Klaus J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949744/
https://www.ncbi.nlm.nih.gov/pubmed/24618687
http://dx.doi.org/10.1371/journal.pone.0091223

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949744/
https://www.ncbi.nlm.nih.gov/pubmed/24618687
http://dx.doi.org/10.1371/journal.pone.0091223

Ejemplares similares