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Prooxidant Properties of p66shc Are Mediated by Mitochondria in Human Cells
p66shc is a protein product of an mRNA isoform of SHC1 gene that has a pro-oxidant and pro-apoptotic activity and is implicated in the aging process. Mitochondria were suggested as a major source of the p66shc-mediated production of reactive oxygen species (ROS), although the underlying mechanisms a...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950296/ https://www.ncbi.nlm.nih.gov/pubmed/24618848 http://dx.doi.org/10.1371/journal.pone.0086521 |