TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy

Base damage and topoisomerase I (Top1)-linked DNA breaks are abundant forms of endogenous DNA breakage, contributing to hereditary ataxia and underlying the cytotoxicity of a wide range of anti-cancer agents. Despite their frequency, the overlapping mechanisms that repair these forms of DNA breakage...

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Detalles Bibliográficos
Autores principales: Alagoz, Meryem, Wells, Owen S., El-Khamisy, Sherif F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950670/
https://www.ncbi.nlm.nih.gov/pubmed/24335147
http://dx.doi.org/10.1093/nar/gkt1260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950670/
https://www.ncbi.nlm.nih.gov/pubmed/24335147
http://dx.doi.org/10.1093/nar/gkt1260

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