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Transient kinetics measured with force steps discriminate between double-stranded DNA elongation and melting and define the reaction energetics
Under a tension of ∼65 pN, double-stranded DNA undergoes an overstretching transition from its basic (B-form) conformation to a 1.7 times longer conformation whose nature is only recently starting to be understood. Here we provide a structural and thermodynamic characterization of the transition by...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950695/ https://www.ncbi.nlm.nih.gov/pubmed/24353317 http://dx.doi.org/10.1093/nar/gkt1297 |