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Nucleosomes accelerate transcription factor dissociation

Transcription factors (TF) bind DNA-target sites within promoters to activate gene expression. TFs target their DNA-recognition sequences with high specificity by binding with resident times of up to hours in vitro. However, in vivo TFs can exchange on the order of seconds. The factors that regulate...

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Detalles Bibliográficos
Autores principales: Luo, Yi, North, Justin A., Rose, Sean D., Poirier, Michael G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950707/
https://www.ncbi.nlm.nih.gov/pubmed/24353316
http://dx.doi.org/10.1093/nar/gkt1319