Inhibition of translation by IFIT family members is determined by their ability to interact selectively with the 5′-terminal regions of cap0-, cap1- and 5′ppp- mRNAs

Ribosomal recruitment of cellular mRNAs depends on binding of eIF4F to the mRNA’s 5′-terminal ‘cap’. The minimal ‘cap0’ consists of N7-methylguanosine linked to the first nucleotide via a 5′-5′ triphosphate (ppp) bridge. Cap0 is further modified by 2′-O-methylation of the next two riboses, yielding...

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Detalles Bibliográficos
Autores principales: Kumar, Parimal, Sweeney, Trevor R., Skabkin, Maxim A., Skabkina, Olga V., Hellen, Christopher U. T., Pestova, Tatyana V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950709/
https://www.ncbi.nlm.nih.gov/pubmed/24371270
http://dx.doi.org/10.1093/nar/gkt1321

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950709/
https://www.ncbi.nlm.nih.gov/pubmed/24371270
http://dx.doi.org/10.1093/nar/gkt1321

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