An H2A histone isotype regulates estrogen receptor target genes by mediating enhancer-promoter-3′-UTR interactions in breast cancer cells

A replication-dependent histone H2A isotype, H2ac, is upregulated in MCF-7 cells and in estrogen receptor-positive clinical breast cancer tissues. Cellular depletion of this H2A isotype leads to defective estrogen signaling, loss of cell proliferation and cell cycle arrest at G0/G1 phase. H2ac media...

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Detalles Bibliográficos
Autores principales: Su, Chia-Hsin, Tzeng, Tsai-Yu, Cheng, Ching, Hsu, Ming-Ta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950719/
https://www.ncbi.nlm.nih.gov/pubmed/24371278
http://dx.doi.org/10.1093/nar/gkt1341

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950719/
https://www.ncbi.nlm.nih.gov/pubmed/24371278
http://dx.doi.org/10.1093/nar/gkt1341

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