Cargando…

Antitumour activity of the recombination polypeptide GST-NT21MP is mediated by inhibition of CXCR4 pathway in breast cancer

BACKGROUND: CXC chemokine receptor 4 (CXCR4) and its ligand stromal cell-derived factor-1α (SDF-1α, also known as CXCL12) have important roles in promoting tumour growth and metastasis. Therefore, targeting CXCR4 could be a promising strategy for treatment of human cancer. METHODS: To achieve this g...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Q, Zhang, F, Ding, Y, Huang, J, Chen, S, Wu, Q, Wang, Z, Chen, C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Molecular Diagnostics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950870/ https://www.ncbi.nlm.nih.gov/pubmed/24448360 http://dx.doi.org/10.1038/bjc.2014.1

Ejemplares similares

Blockade of SDF-1/CXCR4 signalling inhibits pancreatic cancer progression in vitro via inactivation of canonical Wnt pathway
por: Wang, Z, et al.
Publicado: (2008)

Inhibition of Akt sensitises neuroblastoma cells to gold(III) porphyrin 1a, a novel antitumour drug induced apoptosis and growth inhibition
por: Li, W, et al.
Publicado: (2009)

Clinical significance of polypeptide N-acetylgalactosaminyl transferase-5 (GalNAc-T5) expression in patients with gastric cancer
por: He, H, et al.
Publicado: (2014)

Polymorphisms of glutathione S-transferases (GST) and thymidylate synthase (TS) – novel predictors for response and survival in gastric cancer patients
por: Goekkurt, E, et al.
Publicado: (2006)

Polypeptide N-acetylgalactosaminyltransferase 6 expression in pancreatic cancer is an independent prognostic factor indicating better overall survival
por: Li, Z, et al.
Publicado: (2011)

CXCR1 and CXCR2 enhances human melanoma tumourigenesis, growth and invasion
por: Singh, S, et al.
Publicado: (2009)

CXCR3/CCR5 pathways in metastatic melanoma patients treated with adoptive therapy and interleukin-2
por: Bedognetti, D, et al.
Publicado: (2013)

CXCR4/CXCR7/CXCL12 axis promotes an invasive phenotype in medullary thyroid carcinoma
por: Werner, Thomas A, et al.
Publicado: (2017)

CXCR7 expression is associated with disease-free and disease-specific survival in cervical cancer patients
por: Schrevel, M, et al.
Publicado: (2012)

Tumour-initiating capacity is independent of epithelial–mesenchymal transition status in breast cancer cell lines
por: Xie, G, et al.
Publicado: (2014)

miR-21, miR-17 and miR-19a induced by phosphatase of regenerating liver-3 promote the proliferation and metastasis of colon cancer
por: Zhang, J, et al.
Publicado: (2012)

NT5E CpG island methylation is a favourable breast cancer biomarker
por: Lo Nigro, C, et al.
Publicado: (2012)

LSD1-mediated epigenetic modification contributes to proliferation and metastasis of colon cancer
por: Ding, J, et al.
Publicado: (2013)

A nanomaterial-based breath test for distinguishing gastric cancer from benign gastric conditions
por: Xu, Z-q, et al.
Publicado: (2013)

Modification of N staging systems for penile cancer: a more precise prediction of prognosis
por: Li, Z-S, et al.
Publicado: (2015)

NT5E (CD73) is epigenetically regulated in malignant melanoma and associated with metastatic site specificity
por: Wang, H, et al.
Publicado: (2012)

FMNL2 destabilises COMMD10 to activate NF-κB pathway in invasion and metastasis of colorectal cancer
por: Yang, S S, et al.
Publicado: (2017)

Detection of human parvovirus B19 in papillary thyroid carcinoma
por: Wang, J H, et al.
Publicado: (2008)

Antitumour and biological effects of letrozole and GnRH analogue as primary therapy in premenopausal women with ER and PgR positive locally advanced operable breast cancer
por: Torrisi, R, et al.
Publicado: (2007)

miR-367 promotes epithelial-to-mesenchymal transition and invasion of pancreatic ductal adenocarcinoma cells by targeting the Smad7-TGF-β signalling pathway
por: Zhu, Z, et al.
Publicado: (2015)

Dissemination of hepatocellular carcinoma is mediated via chemokine receptor CXCR4
por: Schimanski, C C, et al.
Publicado: (2006)

Dp44mT targets the AKT, TGF-β and ERK pathways via the metastasis suppressor NDRG1 in normal prostate epithelial cells and prostate cancer cells
por: Dixon, K M, et al.
Publicado: (2013)

Long non-coding RNA MALAT1 promotes tumour growth and metastasis in colorectal cancer through binding to SFPQ and releasing oncogene PTBP2 from SFPQ/PTBP2 complex
por: Ji, Q, et al.
Publicado: (2014)

MiR-224 promotes the chemoresistance of human lung adenocarcinoma cells to cisplatin via regulating G(1)/S transition and apoptosis by targeting p21(WAF1/CIP1)
por: Wang, H, et al.
Publicado: (2014)

Leucine-rich repeat-containing G-protein-coupled receptor 5 is associated with invasion, metastasis, and could be a potential therapeutic target in human gastric cancer
por: Xi, H Q, et al.
Publicado: (2014)

High FoxP3 expression in tumour cells predicts better survival in gastric cancer and its role in tumour microenvironment
por: Ma, G-F, et al.
Publicado: (2014)

Effect of the chemokine receptor CXCR7 on proliferation of carcinoma cells in vitro and in vivo
por: Meijer, J, et al.
Publicado: (2008)

Polypeptide N-acetylgalactosaminyl transferase 3 independently predicts high-grade tumours and poor prognosis in patients with renal cell carcinomas
por: Kitada, S, et al.
Publicado: (2013)

High expression of CXCR4 may predict poor survival in resected pancreatic adenocarcinoma
por: Maréchal, R, et al.
Publicado: (2009)

MicroRNA expression profiling identifies miR-328 regulates cancer stem cell-like SP cells in colorectal cancer
por: Xu, X T, et al.
Publicado: (2012)

Expression of SDF-1α and nuclear CXCR4 predicts lymph node metastasis in colorectal cancer
por: Yoshitake, N, et al.
Publicado: (2008)

Alternative implication of CXCR4 in JAK2/STAT3 activation in small cell lung cancer
por: Pfeiffer, M, et al.
Publicado: (2009)

Expression of interferon-γ in human adrenal gland and kidney tumours
por: Li, Q, et al.
Publicado: (2007)

A novel staging model to classify oesophageal squamous cell carcinoma patients in China
por: Tan, H, et al.
Publicado: (2014)

MicroRNA-145 inhibits tumour growth and metastasis in colorectal cancer by targeting fascin-1
por: Feng, Y, et al.
Publicado: (2014)

In ovarian cancer the prognostic influence of HER2/neu is not dependent on the CXCR4/SDF-1 signalling pathway
por: Pils, D, et al.
Publicado: (2007)

Interleukin-8 and its receptor CXCR2 in the tumour microenvironment promote colon cancer growth, progression and metastasis
por: Lee, Y S, et al.
Publicado: (2012)

ALDH1A3 affects colon cancer in vitro proliferation and invasion depending on CXCR4 status
por: Feng, Hailiang, et al.
Publicado: (2018)

CXCL9 induces chemotaxis, chemorepulsion and endothelial barrier disruption through CXCR3-mediated activation of melanoma cells
por: Amatschek, S, et al.
Publicado: (2011)

HIF2α is involved in the expansion of CXCR4-positive cancer stem-like cells in renal cell carcinoma
por: Micucci, Carla, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_6lhfv1us4qcqmpo52k4a739udu