The cAMP phosphodiesterase-4D7 (PDE4D7) is downregulated in androgen-independent prostate cancer cells and mediates proliferation by compartmentalising cAMP at the plasma membrane of VCaP prostate cancer cells

BACKGROUND: Isoforms of the PDE4 family of cAMP-specific phosphodiesterases (PDEs) are expressed in a cell type-dependent manner and contribute to underpinning the paradigm of intracellular cAMP signal compartmentalisation. Here we identify the differential regulation of the PDE4D7 isoform during pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Henderson, D J P, Byrne, A, Dulla, K, Jenster, G, Hoffmann, R, Baillie, G S, Houslay, M D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950871/
https://www.ncbi.nlm.nih.gov/pubmed/24518597
http://dx.doi.org/10.1038/bjc.2014.22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950871/
https://www.ncbi.nlm.nih.gov/pubmed/24518597
http://dx.doi.org/10.1038/bjc.2014.22

Ejemplares similares