NBN Phosphorylation regulates the accumulation of MRN and ATM at sites of DNA Double-Strand Breaks

In response to ionizing radiation, the MRE11/RAD50/NBN (MRN) complex re-distributes to the sites of DNA double strand breaks (DSBs) where each of its individual components is phosphorylated by the serine-threonine kinase, ATM. ATM phosphorylation of NBN is required for activation of the S-phase chec...

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Detalles Bibliográficos
Autores principales: Wen, Jie, Cerosaletti, Karen, Schultz, Katherine J., Wright, Jocyndra A., Concannon, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951136/
https://www.ncbi.nlm.nih.gov/pubmed/23146902
http://dx.doi.org/10.1038/onc.2012.443

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951136/
https://www.ncbi.nlm.nih.gov/pubmed/23146902
http://dx.doi.org/10.1038/onc.2012.443

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