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Simple, Chemoselective Hydrogenation with Thermodynamic Stereocontrol
[Image: see text] Few methods permit the hydrogenation of alkenes to a thermodynamically favored configuration when steric effects dictate the alternative trajectory of hydrogen delivery. Dissolving metal reduction achieves this control, but with extremely low functional group tolerance. Here we dem...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951266/ https://www.ncbi.nlm.nih.gov/pubmed/24428640 http://dx.doi.org/10.1021/ja412342g |
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author | Iwasaki, Kotaro Wan, Kanny K. Oppedisano, Alberto Crossley, Steven W. M. Shenvi, Ryan A. |
author_facet | Iwasaki, Kotaro Wan, Kanny K. Oppedisano, Alberto Crossley, Steven W. M. Shenvi, Ryan A. |
author_sort | Iwasaki, Kotaro |
collection | PubMed |
description | [Image: see text] Few methods permit the hydrogenation of alkenes to a thermodynamically favored configuration when steric effects dictate the alternative trajectory of hydrogen delivery. Dissolving metal reduction achieves this control, but with extremely low functional group tolerance. Here we demonstrate a catalytic hydrogenation of alkenes that affords the thermodynamic alkane products with remarkably broad functional group compatibility and rapid reaction rates at standard temperature and pressure. |
format | Online Article Text |
id | pubmed-3951266 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | American Chemical
Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-39512662015-01-15 Simple, Chemoselective Hydrogenation with Thermodynamic Stereocontrol Iwasaki, Kotaro Wan, Kanny K. Oppedisano, Alberto Crossley, Steven W. M. Shenvi, Ryan A. J Am Chem Soc [Image: see text] Few methods permit the hydrogenation of alkenes to a thermodynamically favored configuration when steric effects dictate the alternative trajectory of hydrogen delivery. Dissolving metal reduction achieves this control, but with extremely low functional group tolerance. Here we demonstrate a catalytic hydrogenation of alkenes that affords the thermodynamic alkane products with remarkably broad functional group compatibility and rapid reaction rates at standard temperature and pressure. American Chemical Society 2014-01-15 2014-01-29 /pmc/articles/PMC3951266/ /pubmed/24428640 http://dx.doi.org/10.1021/ja412342g Text en Copyright © 2014 American Chemical Society |
spellingShingle | Iwasaki, Kotaro Wan, Kanny K. Oppedisano, Alberto Crossley, Steven W. M. Shenvi, Ryan A. Simple, Chemoselective Hydrogenation with Thermodynamic Stereocontrol |
title | Simple,
Chemoselective Hydrogenation with Thermodynamic
Stereocontrol |
title_full | Simple,
Chemoselective Hydrogenation with Thermodynamic
Stereocontrol |
title_fullStr | Simple,
Chemoselective Hydrogenation with Thermodynamic
Stereocontrol |
title_full_unstemmed | Simple,
Chemoselective Hydrogenation with Thermodynamic
Stereocontrol |
title_short | Simple,
Chemoselective Hydrogenation with Thermodynamic
Stereocontrol |
title_sort | simple,
chemoselective hydrogenation with thermodynamic
stereocontrol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951266/ https://www.ncbi.nlm.nih.gov/pubmed/24428640 http://dx.doi.org/10.1021/ja412342g |
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