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Simple, Chemoselective Hydrogenation with Thermodynamic Stereocontrol

[Image: see text] Few methods permit the hydrogenation of alkenes to a thermodynamically favored configuration when steric effects dictate the alternative trajectory of hydrogen delivery. Dissolving metal reduction achieves this control, but with extremely low functional group tolerance. Here we dem...

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Detalles Bibliográficos
Autores principales: Iwasaki, Kotaro, Wan, Kanny K., Oppedisano, Alberto, Crossley, Steven W. M., Shenvi, Ryan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951266/
https://www.ncbi.nlm.nih.gov/pubmed/24428640
http://dx.doi.org/10.1021/ja412342g
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author Iwasaki, Kotaro
Wan, Kanny K.
Oppedisano, Alberto
Crossley, Steven W. M.
Shenvi, Ryan A.
author_facet Iwasaki, Kotaro
Wan, Kanny K.
Oppedisano, Alberto
Crossley, Steven W. M.
Shenvi, Ryan A.
author_sort Iwasaki, Kotaro
collection PubMed
description [Image: see text] Few methods permit the hydrogenation of alkenes to a thermodynamically favored configuration when steric effects dictate the alternative trajectory of hydrogen delivery. Dissolving metal reduction achieves this control, but with extremely low functional group tolerance. Here we demonstrate a catalytic hydrogenation of alkenes that affords the thermodynamic alkane products with remarkably broad functional group compatibility and rapid reaction rates at standard temperature and pressure.
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spelling pubmed-39512662015-01-15 Simple, Chemoselective Hydrogenation with Thermodynamic Stereocontrol Iwasaki, Kotaro Wan, Kanny K. Oppedisano, Alberto Crossley, Steven W. M. Shenvi, Ryan A. J Am Chem Soc [Image: see text] Few methods permit the hydrogenation of alkenes to a thermodynamically favored configuration when steric effects dictate the alternative trajectory of hydrogen delivery. Dissolving metal reduction achieves this control, but with extremely low functional group tolerance. Here we demonstrate a catalytic hydrogenation of alkenes that affords the thermodynamic alkane products with remarkably broad functional group compatibility and rapid reaction rates at standard temperature and pressure. American Chemical Society 2014-01-15 2014-01-29 /pmc/articles/PMC3951266/ /pubmed/24428640 http://dx.doi.org/10.1021/ja412342g Text en Copyright © 2014 American Chemical Society
spellingShingle Iwasaki, Kotaro
Wan, Kanny K.
Oppedisano, Alberto
Crossley, Steven W. M.
Shenvi, Ryan A.
Simple, Chemoselective Hydrogenation with Thermodynamic Stereocontrol
title Simple, Chemoselective Hydrogenation with Thermodynamic Stereocontrol
title_full Simple, Chemoselective Hydrogenation with Thermodynamic Stereocontrol
title_fullStr Simple, Chemoselective Hydrogenation with Thermodynamic Stereocontrol
title_full_unstemmed Simple, Chemoselective Hydrogenation with Thermodynamic Stereocontrol
title_short Simple, Chemoselective Hydrogenation with Thermodynamic Stereocontrol
title_sort simple, chemoselective hydrogenation with thermodynamic stereocontrol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951266/
https://www.ncbi.nlm.nih.gov/pubmed/24428640
http://dx.doi.org/10.1021/ja412342g
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