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Nonvesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids
Phosphorylated sphingolipids [ceramide-1-phosphate (C1P) and sphingosine-1-phosphate (S1P)] have emerged as key regulators of cell growth, survival, migration, and inflammation(1–5). C1P (Fig. 1a) produced by ceramide kinase is an activator of group IVA cytosolic phospholipase A(2)α (cPLA(2)α), the...
Autores principales: | Simanshu, Dhirendra K., Kamlekar, Ravi Kanth, Wijesinghe, Dayanjan S., Zou, Xianqiong, Zhai, Xiuhong, Mishra, Shrawan K., Molotkovsky, Julian G., Malinina, Lucy, Hinchcliffe, Edward H., Chalfant, Charles E., Brown, Rhoderick E., Patel, Dinshaw J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951269/ https://www.ncbi.nlm.nih.gov/pubmed/23863933 http://dx.doi.org/10.1038/nature12332 |
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