Phase I Randomized Clinical Trial of VRC DNA and rAd5 HIV-1 Vaccine Delivery by Intramuscular (IM), Subcutaneous (SC) and Intradermal (ID) Administration (VRC 011)

BACKGROUND: Phase 1 evaluation of the VRC HIV DNA and rAd5 vaccines delivered intramuscularly (IM) supported proceeding to a Phase 2 b efficacy study. Here we report comparison of the IM, subcutaneous (SC) and intradermal (ID) routes of administration. METHODS: Sixty subjects were randomized to 6 sc...

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Detalles Bibliográficos
Autores principales: Enama, Mary E., Ledgerwood, Julie E., Novik, Laura, Nason, Martha C., Gordon, Ingelise J., Holman, LaSonji, Bailer, Robert T., Roederer, Mario, Koup, Richard A., Mascola, John R., Nabel, Gary J., Graham, Barney S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951381/
https://www.ncbi.nlm.nih.gov/pubmed/24621858
http://dx.doi.org/10.1371/journal.pone.0091366

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951381/
https://www.ncbi.nlm.nih.gov/pubmed/24621858
http://dx.doi.org/10.1371/journal.pone.0091366

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