A propofol binding site on mammalian GABA(A) receptors identified by photolabeling

Propofol is the most important intravenous general anesthetic in current clinical use. It acts by potentiating GABA(A) receptors, but where it binds to this receptor is not known and has been a matter of some controversy. We have synthesized a novel propofol analogue photolabeling reagent that has a...

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Detalles Bibliográficos
Autores principales: Yip, Grace M S, Chen, Zi-Wei, Edge, Christopher J, Smith, Edward H, Dickinson, Robert, Hohenester, Erhard, Townsend, R Reid, Fuchs, Karoline, Sieghart, Werner, Evers, Alex S, Franks, Nicholas P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951778/
https://www.ncbi.nlm.nih.gov/pubmed/24056400
http://dx.doi.org/10.1038/nchembio.1340

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951778/
https://www.ncbi.nlm.nih.gov/pubmed/24056400
http://dx.doi.org/10.1038/nchembio.1340

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