A Kinetic Model Explains Why Shorter and Less Affine Enzyme-recruiting Oligonucleotides Can Be More Potent

Antisense oligonucleotides complementary to RNA targets promise generality and ease of drug design. The first systemically administered antisense drug was recently approved for treatment and others are in clinical development. Chemical modifications that increase the hybridization affinity of oligon...

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Detalles Bibliográficos
Autores principales: Pedersen, Lykke, Hagedorn, Peter H, Lindholm, Marie Wickström, Lindow, Morten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951909/
https://www.ncbi.nlm.nih.gov/pubmed/24549300
http://dx.doi.org/10.1038/mtna.2013.72

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951909/
https://www.ncbi.nlm.nih.gov/pubmed/24549300
http://dx.doi.org/10.1038/mtna.2013.72

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