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A conservation and rigidity based method for detecting critical protein residues

BACKGROUND: Certain amino acids in proteins play a critical role in determining their structural stability and function. Examples include flexible regions such as hinges which allow domain motion, and highly conserved residues on functional interfaces which allow interactions with other proteins. De...

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Detalles Bibliográficos
Autores principales: Akbal-Delibas, Bahar, Jagodzinski, Filip, Haspel, Nurit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952096/
https://www.ncbi.nlm.nih.gov/pubmed/24565061
http://dx.doi.org/10.1186/1472-6807-13-S1-S6