Spatio-Temporal Simulation of First Pass Drug Perfusion in the Liver

The liver is the central organ for detoxification of xenobiotics in the body. In pharmacokinetic modeling, hepatic metabolization capacity is typically quantified as hepatic clearance computed as degradation in well-stirred compartments. This is an accurate mechanistic description once a quasi-equil...

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Detalles Bibliográficos
Autores principales: Schwen, Lars Ole, Krauss, Markus, Niederalt, Christoph, Gremse, Felix, Kiessling, Fabian, Schenk, Andrea, Preusser, Tobias, Kuepfer, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952820/
https://www.ncbi.nlm.nih.gov/pubmed/24625393
http://dx.doi.org/10.1371/journal.pcbi.1003499

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952820/
https://www.ncbi.nlm.nih.gov/pubmed/24625393
http://dx.doi.org/10.1371/journal.pcbi.1003499

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