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Spatio-Temporal Simulation of First Pass Drug Perfusion in the Liver
The liver is the central organ for detoxification of xenobiotics in the body. In pharmacokinetic modeling, hepatic metabolization capacity is typically quantified as hepatic clearance computed as degradation in well-stirred compartments. This is an accurate mechanistic description once a quasi-equil...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952820/ https://www.ncbi.nlm.nih.gov/pubmed/24625393 http://dx.doi.org/10.1371/journal.pcbi.1003499 |