The ShcD signaling adaptor facilitates ligand-independent phosphorylation of the EGF receptor

Proto-oncogenic Src homology and collagen (Shc) proteins have been considered archetypal adaptors of epidermal growth factor receptor (EGFR)–mediated signaling. We report that in addition to its role as an EGFR-binding partner and Grb2 platform, ShcD acts noncanonically to promote phosphorylation of...

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Detalles Bibliográficos
Autores principales: Wills, Melanie K. B., Tong, Jiefei, Tremblay, Sylvie L., Moran, Michael F., Jones, Nina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952845/
https://www.ncbi.nlm.nih.gov/pubmed/24430869
http://dx.doi.org/10.1091/mbc.E13-08-0434

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952845/
https://www.ncbi.nlm.nih.gov/pubmed/24430869
http://dx.doi.org/10.1091/mbc.E13-08-0434

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