Calpain-mediated proteolysis of tropomodulin isoforms leads to thin filament elongation in dystrophic skeletal muscle

Duchenne muscular dystrophy (DMD) induces sarcolemmal mechanical instability and rupture, hyperactivity of intracellular calpains, and proteolytic breakdown of muscle structural proteins. Here we identify the two sarcomeric tropomodulin (Tmod) isoforms, Tmod1 and Tmod4, as novel proteolytic targets...

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Detalles Bibliográficos
Autores principales: Gokhin, David S., Tierney, Matthew T., Sui, Zhenhua, Sacco, Alessandra, Fowler, Velia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952854/
https://www.ncbi.nlm.nih.gov/pubmed/24430868
http://dx.doi.org/10.1091/mbc.E13-10-0608

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952854/
https://www.ncbi.nlm.nih.gov/pubmed/24430868
http://dx.doi.org/10.1091/mbc.E13-10-0608

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