The Drosophila insulin-degrading enzyme restricts growth by modulating the PI3K pathway in a cell-autonomous manner

Mammalian insulin-degrading enzyme (IDE) cleaves insulin, among other peptidic substrates, but its function in insulin signaling is elusive. We use the Drosophila system to define the function of IDE in the regulation of growth and metabolism. We find that either loss or gain of function of Drosophi...

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Detalles Bibliográficos
Autores principales: Galagovsky, Diego, Katz, Maximiliano J., Acevedo, Julieta M., Sorianello, Eleonora, Glavic, Alvaro, Wappner, Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952859/
https://www.ncbi.nlm.nih.gov/pubmed/24430872
http://dx.doi.org/10.1091/mbc.E13-04-0213

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952859/
https://www.ncbi.nlm.nih.gov/pubmed/24430872
http://dx.doi.org/10.1091/mbc.E13-04-0213

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