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A population-based evolutionary search approach to the multiple minima problem in de novo protein structure prediction

BACKGROUND: Elucidating the native structure of a protein molecule from its sequence of amino acids, a problem known as de novo structure prediction, is a long standing challenge in computational structural biology. Difficulties in silico arise due to the high dimensionality of the protein conformat...

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Detalles Bibliográficos
Autores principales: Saleh, Sameh, Olson, Brian, Shehu, Amarda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953177/
https://www.ncbi.nlm.nih.gov/pubmed/24565020
http://dx.doi.org/10.1186/1472-6807-13-S1-S4