Cargando…

DNA and Protein Co-Immunization Improves the Magnitude and Longevity of Humoral Immune Responses in Macaques

We tested the concept of combining DNA with protein to improve anti-HIV Env systemic and mucosal humoral immune responses. Rhesus macaques were vaccinated with DNA, DNA&protein co-immunization or DNA prime followed by protein boost, and the magnitude and mucosal dissemination of the antibody res...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jalah, Rashmi, Kulkarni, Viraj, Patel, Vainav, Rosati, Margherita, Alicea, Candido, Bear, Jenifer, Yu, Lei, Guan, Yongjun, Shen, Xiaoying, Tomaras, Georgia D., LaBranche, Celia, Montefiori, David C., Prattipati, Rajasekhar, Pinter, Abraham, Bess, Julian, Lifson, Jeffrey D., Reed, Steven G., Sardesai, Niranjan Y., Venzon, David J., Valentin, Antonio, Pavlakis, George N., Felber, Barbara K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953433/ https://www.ncbi.nlm.nih.gov/pubmed/24626482 http://dx.doi.org/10.1371/journal.pone.0091550

Ejemplares similares

Dose-dependent inhibition of Gag cellular immunity by Env in SIV/HIV DNA vaccinated macaques
por: Valentin, Antonio, et al.
Publicado: (2015)

DNA vaccination by intradermal electroporation induces long-lasting immune responses in rhesus macaques
por: Kulkarni, Viraj, et al.
Publicado: (2014)

Preservation of a subset of SIV-specific central memory CD4+ T cells correlates with control of viremia in SIVmac251 infected macaques
por: Felber, Barbara K, et al.
Publicado: (2006)

RTE and CTE mRNA export elements synergistically increase expression of unstable, Rev-dependent HIV and SIV mRNAs
por: Smulevitch, Sergey, et al.
Publicado: (2006)

Intramuscular delivery of heterodimeric IL-15 DNA in macaques produces systemic levels of bioactive cytokine inducing proliferation of NK and T cells
por: Bergamaschi, C, et al.
Publicado: (2015)

Co-immunization with HIV Env DNA and protein elicit long-lasting strong cellular and humoral immune responses
por: Li, J, et al.
Publicado: (2012)

Control of Heterologous Simian Immunodeficiency Virus SIV(smE660) Infection by DNA and Protein Coimmunization Regimens Combined with Different Toll-Like-Receptor-4-Based Adjuvants in Macaques
por: Singh, Shakti, et al.
Publicado: (2018)

The p40 Subunit of Interleukin (IL)-12 Promotes Stabilization and Export of the p35 Subunit: IMPLICATIONS FOR IMPROVED IL-12 CYTOKINE PRODUCTION
por: Jalah, Rashmi, et al.
Publicado: (2013)

Altered Response Hierarchy and Increased T-Cell Breadth upon HIV-1 Conserved Element DNA Vaccination in Macaques
por: Kulkarni, Viraj, et al.
Publicado: (2014)

HIV Env conserved element DNA vaccine alters immunodominance in macaques
por: Hu, Xintao, et al.
Publicado: (2017)

Priming with DNA Expressing Trimeric HIV V1V2 Alters the Immune Hierarchy Favoring the Development of V2-Specific Antibodies in Rhesus Macaques
por: Devasundaram, Santhi, et al.
Publicado: (2020)

A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques
por: Mothe, Beatriz, et al.
Publicado: (2015)

HIV-1 p24(gag) Derived Conserved Element DNA Vaccine Increases the Breadth of Immune Response in Mice
por: Kulkarni, Viraj, et al.
Publicado: (2013)

Treatment with native heterodimeric IL-15 increases cytotoxic lymphocytes and reduces SHIV RNA in lymph nodes
por: Watson, Dionysios C., et al.
Publicado: (2018)

Correction: Treatment with native heterodimeric IL-15 increases cytotoxic lymphocytes and reduces SHIV RNA in lymph nodes
por: Watson, Dionysios C., et al.
Publicado: (2018)

Step-dose IL-7 treatment promotes systemic expansion of T cells and alters immune cell landscape in blood and lymph nodes
por: Pandit, Hrishikesh, et al.
Publicado: (2023)

Breadth and magnitude of antigen-specific antibody responses in the control of plasma viremia in simian immunodeficiency virus infected macaques
por: Pahar, Bapi, et al.
Publicado: (2016)

Heterodimeric IL-15 regulates the differentiation and survival of different populations of memory T cells and the balance of effector and regulatory cells
por: Pavlakis, George N, et al.
Publicado: (2013)

E4orf1 Suppresses E1B-Deleted Adenovirus Vaccine-Induced Immune Responses
por: Sangare, Kotou, et al.
Publicado: (2022)

DNA is an efficient booster of dendritic cell-based vaccine
por: Li, Jinyao, et al.
Publicado: (2015)

P18-09. Persistent virological benefit in SIV-infected macaques upon therapeutic vaccination upon vaccination with DNA vectors
por: Felber, BK, et al.
Publicado: (2009)

Nuclear export factor RBM15 facilitates the access of DBP5 to mRNA
por: Zolotukhin, Andrei S., et al.
Publicado: (2009)

Mucosal Immunization with Newcastle Disease Virus Vector Coexpressing HIV-1 Env and Gag Proteins Elicits Potent Serum, Mucosal, and Cellular Immune Responses That Protect against Vaccinia Virus Env and Gag Challenges
por: Khattar, Sunil K., et al.
Publicado: (2015)

Control of SARS-CoV-2 infection after Spike DNA or Spike DNA+Protein co-immunization in rhesus macaques
por: Rosati, Margherita, et al.
Publicado: (2021)

HIV-1 Conserved Elements p24CE DNA Vaccine Induces Humoral Immune Responses with Broad Epitope Recognition in Macaques
por: Kulkarni, Viraj, et al.
Publicado: (2014)

Antibody Response to COVID-19 mRNA Vaccine in Patients with Multiple Myeloma and Waldenstrom's Macroglobulinemia after Primary Immunization and Booster: Reactivity to the Sars-Cov-2 WT Virus, Delta and Omicron Variants
por: Terpos, Evangelos, et al.
Publicado: (2022)

DNA vaccines expressing conserved elements provide potent and broad immune responses
por: Pavlakis, GN, et al.
Publicado: (2012)

Sequential Analysis of Binding and Neutralizing Antibody in COVID-19 Convalescent Patients at 14 Months After SARS-CoV-2 Infection
por: Rosati, Margherita, et al.
Publicado: (2021)

HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge
por: Jones, Andrew T., et al.
Publicado: (2019)

A minimal T-cell immunogen designed to cover HIV-1 specificities associated with control is immunogenic in mice and breaks CTL immunodominance
por: Mothe, B, et al.
Publicado: (2012)

P14-08. Intramuscular DNA delivery by electroporation leads to greatly enhanced systemic and mucosal immune responses and control of SIVmac251 challenge
por: Pavlakis, GN, et al.
Publicado: (2009)

Optimized administration of hetIL-15 expands lymphocytes and minimizes toxicity in rhesus macaques
por: Bergamaschi, Cristina, et al.
Publicado: (2018)

CTLA-4 Blockade, during HIV Virus-Like Particles Immunization, Alters HIV-Specific B-Cell Responses
por: Lewis, Phoebe E., et al.
Publicado: (2020)

Immunization with an SIV-based IDLV Expressing HIV-1 Env 1086 Clade C Elicits Durable Humoral and Cellular Responses in Rhesus Macaques
por: Negri, Donatella, et al.
Publicado: (2016)

Systemic IL-15, IFN-γ, and IP-10/CXCL10 signature associated with effective immune response to SARS-CoV-2 in BNT162b2 mRNA vaccine recipients
por: Bergamaschi, Cristina, et al.
Publicado: (2021)

Adjuvants influence the maturation of VRC01-like antibodies during immunization
por: Knudsen, Maria L., et al.
Publicado: (2022)

Immunization of Rabbits with Highly Purified, Soluble, Trimeric Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Induces a Vigorous B Cell Response and Broadly Cross-Reactive Neutralization
por: Quinnan, Gerald V., et al.
Publicado: (2014)

Eliciting broadly neutralizing antibodies against HIV-1 that target gp41 MPER
por: Han, D, et al.
Publicado: (2012)

Retraction: eliciting broadly neutralizing antibodies against HIV-1 that target gp41 MPER
por: Han, D, et al.
Publicado: (2014)

The Impact of Sustained Immunization Regimens on the Antibody Response to Oligomannose Glycans
por: Nguyen, Dung N., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_9rgsgor4es00oivtv6mpgrotd0