Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes

Phenotypic screening is making a comeback in drug discovery as the maturation of chemical proteomics methods has facilitated target identification for bioactive small molecules. A limitation of these approaches is that time-consuming genetic methods or other means is often required to determine the...

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Detalles Bibliográficos
Autores principales: Dominguez, Eduardo, Galmozzi, Andrea, Chang, Jae Won, Hsu, Ku-Lung, Pawlak, Joanna, Li, Weiwei, Godio, Cristina, Thomas, Jason, Partida, David, Niessen, Sherry, O'Brien, Paul E., Russell, Aaron P., Watt, Matthew J., Nomura, Daniel K., Cravatt, Benjamin F., Saez, Enrique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953460/
https://www.ncbi.nlm.nih.gov/pubmed/24362705
http://dx.doi.org/10.1038/nchembio.1429

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953460/
https://www.ncbi.nlm.nih.gov/pubmed/24362705
http://dx.doi.org/10.1038/nchembio.1429

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