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A Stem-Cell Based Bioassay to Critically Assess the Pathology of Dysfunctional Neuromuscular Junctions

Pluripotent stem cells can be directed to differentiate into motor neurons and assessed for functionality in vitro. An emerging application of this technique is to model genetically inherited diseases in differentiated motor neurons and to screen for new therapeutic targets. The neuromuscular juncti...

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Detalles Bibliográficos
Autores principales: Chipman, Peter H., Zhang, Ying, Rafuse, Victor F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953473/
https://www.ncbi.nlm.nih.gov/pubmed/24626225
http://dx.doi.org/10.1371/journal.pone.0091643