Origin and evolution of the Peptidyl Transferase Center from proto-tRNAs

We tested the hypothesis of Tamura (2011) [3] that molecules of tRNA gave origin to ribosomes, particularly to the Peptidyl Transferase Center (PTC) of the 23S ribosomal RNA. We reconstructed the ancestral sequences from all types of tRNA and compared them in their sequences with the current PTC of...

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Autores principales: Farias, Sávio T., Rêgo, Thais G., José, Marco V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953717/
https://www.ncbi.nlm.nih.gov/pubmed/24649398
http://dx.doi.org/10.1016/j.fob.2014.01.010
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author Farias, Sávio T.
Rêgo, Thais G.
José, Marco V.
author_facet Farias, Sávio T.
Rêgo, Thais G.
José, Marco V.
author_sort Farias, Sávio T.
collection PubMed
description We tested the hypothesis of Tamura (2011) [3] that molecules of tRNA gave origin to ribosomes, particularly to the Peptidyl Transferase Center (PTC) of the 23S ribosomal RNA. We reconstructed the ancestral sequences from all types of tRNA and compared them in their sequences with the current PTC of 23S ribosomal RNA from different organisms. We built an ancestral sequence of proto-tRNAs that showed a remarkable overall identity of 50.53% with the catalytic site of PTC. We conclude that the Peptidyl Transferase Center was indeed originated by the fusion of ancestral sequences of proto-tRNA.
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spelling pubmed-39537172014-03-19 Origin and evolution of the Peptidyl Transferase Center from proto-tRNAs Farias, Sávio T. Rêgo, Thais G. José, Marco V. FEBS Open Bio Article We tested the hypothesis of Tamura (2011) [3] that molecules of tRNA gave origin to ribosomes, particularly to the Peptidyl Transferase Center (PTC) of the 23S ribosomal RNA. We reconstructed the ancestral sequences from all types of tRNA and compared them in their sequences with the current PTC of 23S ribosomal RNA from different organisms. We built an ancestral sequence of proto-tRNAs that showed a remarkable overall identity of 50.53% with the catalytic site of PTC. We conclude that the Peptidyl Transferase Center was indeed originated by the fusion of ancestral sequences of proto-tRNA. Elsevier 2014-02-08 /pmc/articles/PMC3953717/ /pubmed/24649398 http://dx.doi.org/10.1016/j.fob.2014.01.010 Text en © 2014 The Authors
spellingShingle Article
Farias, Sávio T.
Rêgo, Thais G.
José, Marco V.
Origin and evolution of the Peptidyl Transferase Center from proto-tRNAs
title Origin and evolution of the Peptidyl Transferase Center from proto-tRNAs
title_full Origin and evolution of the Peptidyl Transferase Center from proto-tRNAs
title_fullStr Origin and evolution of the Peptidyl Transferase Center from proto-tRNAs
title_full_unstemmed Origin and evolution of the Peptidyl Transferase Center from proto-tRNAs
title_short Origin and evolution of the Peptidyl Transferase Center from proto-tRNAs
title_sort origin and evolution of the peptidyl transferase center from proto-trnas
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953717/
https://www.ncbi.nlm.nih.gov/pubmed/24649398
http://dx.doi.org/10.1016/j.fob.2014.01.010
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