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Stabilization of cyclohexanone monooxygenase by a computationally designed disulfide bond spanning only one residue
Enzyme stability is an important parameter in biocatalytic applications, and there is a strong need for efficient methods to generate robust enzymes. We investigated whether stabilizing disulfide bonds can be computationally designed based on a model structure. In our approach, unlike in previous di...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953729/ https://www.ncbi.nlm.nih.gov/pubmed/24649397 http://dx.doi.org/10.1016/j.fob.2014.01.009 |