Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species

TAR DNA-binding protein (TDP-43, also known as TARDBP) is the major pathological protein in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Large TDP-43 aggregates that are decorated with degradation adaptor proteins are seen in the cytoplasm of remaining neurons in ALS and FT...

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Detalles Bibliográficos
Autores principales: Scotter, Emma L., Vance, Caroline, Nishimura, Agnes L., Lee, Youn-Bok, Chen, Han-Jou, Urwin, Hazel, Sardone, Valentina, Mitchell, Jacqueline C., Rogelj, Boris, Rubinsztein, David C., Shaw, Christopher E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953816/
https://www.ncbi.nlm.nih.gov/pubmed/24424030
http://dx.doi.org/10.1242/jcs.140087

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953816/
https://www.ncbi.nlm.nih.gov/pubmed/24424030
http://dx.doi.org/10.1242/jcs.140087

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