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The total burden of rare, non-synonymous exome genetic variants is not associated with childhood or late-life cognitive ability

Human cognitive ability shows consistent, positive associations with fitness components across the life-course. Underlying genetic variation should therefore be depleted by selection, which is not observed. Genetic variation in general cognitive ability (intelligence) could be maintained by a mutati...

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Detalles Bibliográficos
Autores principales: Marioni, Riccardo E., Penke, Lars, Davies, Gail, Huffman, Jennifer E., Hayward, Caroline, Deary, Ian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953855/
https://www.ncbi.nlm.nih.gov/pubmed/24573858
http://dx.doi.org/10.1098/rspb.2014.0117