Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6

Glycogen synthase kinase-3 (GSK-3) is a key regulator of many cellular signaling pathways. Unlike most kinases, GSK-3 is controlled by inhibition rather than by specific activation. In the insulin and several other signaling pathways, phosphorylation of a serine present in a conserved sequence near...

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Detalles Bibliográficos
Autores principales: Stamos, Jennifer L, Chu, Matthew Ling-Hon, Enos, Michael D, Shah, Niket, Weis, William I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953950/
https://www.ncbi.nlm.nih.gov/pubmed/24642411
http://dx.doi.org/10.7554/eLife.01998

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953950/
https://www.ncbi.nlm.nih.gov/pubmed/24642411
http://dx.doi.org/10.7554/eLife.01998

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