Quantum Mechanical/Molecular Mechanical Free Energy Simulations of the Self-Cleavage Reaction in the Hepatitis Delta Virus Ribozyme

[Image: see text] The hepatitis delta virus (HDV) ribozyme catalyzes a self-cleavage reaction using a combination of nucleobase and metal ion catalysis. Both divalent and monovalent ions can catalyze this reaction, although the rate is slower with monovalent ions alone. Herein, we use quantum mechan...

Descripción completa

Detalles Bibliográficos
Autores principales: Ganguly, Abir, Thaplyal, Pallavi, Rosta, Edina, Bevilacqua, Philip C., Hammes-Schiffer, Sharon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954522/
https://www.ncbi.nlm.nih.gov/pubmed/24383543
http://dx.doi.org/10.1021/ja4104217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954522/
https://www.ncbi.nlm.nih.gov/pubmed/24383543
http://dx.doi.org/10.1021/ja4104217

Ejemplares similares