NHC–Cu-Catalyzed Addition of Propargylboron Reagents to Phosphinoylimines. Enantioselective Synthesis of Trimethylsilyl-Substituted Homoallenylamides and Application to the Synthesis of S-(−)-Cyclooroidin

[Image: see text] A catalytic method for the efficient and enantioselective addition of a 1-trimethylsilyl-substituted allene moiety to phosphinoylimines is presented. Transformations are promoted by 5.0 mol % of a copper complex of an N-heterocyclic carbene in the presence of a propargylboron reage...

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Detalles Bibliográficos
Autores principales: Mszar, Nicholas W., Haeffner, Fredrik, Hoveyda, Amir H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954525/
https://www.ncbi.nlm.nih.gov/pubmed/24555471
http://dx.doi.org/10.1021/ja500373s

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954525/
https://www.ncbi.nlm.nih.gov/pubmed/24555471
http://dx.doi.org/10.1021/ja500373s

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