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Asymmetric Synthesis of 2-Substituted Oxetan-3-ones via Metalated SAMP/RAMP Hydrazones

[Image: see text] 2-Substituted oxetan-3-ones can be prepared in good yields and enantioselectivities (up to 84% ee) by the metalation of the SAMP/RAMP hydrazones of oxetan-3-one, followed by reaction with a range of electrophiles that include alkyl, allyl, and benzyl halides. Additionally, both chi...

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Detalles Bibliográficos
Autores principales:	Geden, Joanna V., Beasley, Benjamin O., Clarkson, Guy J., Shipman, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2013
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954718/ https://www.ncbi.nlm.nih.gov/pubmed/24152298 http://dx.doi.org/10.1021/jo4020485

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