Novel Potent Imidazo[1,2-a]pyridine-N-Glycinyl-Hydrazone Inhibitors of TNF-α Production: In Vitro and In Vivo Studies

In this work, we describe the design, synthesis and pharmacological evaluation of novel imidazo[1,2-a]pyridine-N-glycinyl-hydrazone derivatives (1a–k) intended for use as inhibitors of tumor necrosis factor alpha (TNF-α) production. The compounds were designed based on the orally active anti-inflamm...

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Detalles Bibliográficos
Autores principales: Lacerda, Renata B., Sales, Natália M., da Silva, Leandro L., Tesch, Roberta, Miranda, Ana Luisa P., Barreiro, Eliezer J., Fernandes, Patricia D., Fraga, Carlos A. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954757/
https://www.ncbi.nlm.nih.gov/pubmed/24632827
http://dx.doi.org/10.1371/journal.pone.0091660

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954757/
https://www.ncbi.nlm.nih.gov/pubmed/24632827
http://dx.doi.org/10.1371/journal.pone.0091660

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