SFlt-1 Elevates Blood Pressure by Augmenting Endothelin-1-Mediated Vasoconstriction in Mice

OBJECTIVE: Scavenging of vascular endothelial growth factor (VEGF) elevates blood pressure (BP) in patients receiving anti-angiogenic therapy. Similarly, inhibition of circulation VEGF by its soluble receptor fms-like tyrosine kinase-1 (sFlt-1) underlies BP elevation in pre-eclampsia. Both phenotype...

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Detalles Bibliográficos
Autores principales: Amraoui, Fouad, Spijkers, Léon, Hassani Lahsinoui, Hajar, Vogt, Liffert, van der Post, Joris, Peters, Stephan, Afink, Gijs, Ris-Stalpers, Carrie, van den Born, Bert-Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954828/
https://www.ncbi.nlm.nih.gov/pubmed/24632840
http://dx.doi.org/10.1371/journal.pone.0091897

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954828/
https://www.ncbi.nlm.nih.gov/pubmed/24632840
http://dx.doi.org/10.1371/journal.pone.0091897

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