Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

Four agents — acarbose (ACA), 17-α-estradiol (EST), nordihydroguaiaretic acid (NDGA), and methylene blue (MB) — were evaluated for lifespan effects in genetically heterogeneous mice tested at three sites. Acarbose increased male median lifespan by 22% (P < 0.0001), but increased female median lif...

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Detalles Bibliográficos
Autores principales: Harrison, David E, Strong, Randy, Allison, David B, Ames, Bruce N, Astle, Clinton M, Atamna, Hani, Fernandez, Elizabeth, Flurkey, Kevin, Javors, Martin A, Nadon, Nancy L, Nelson, James F, Pletcher, Scott, Simpkins, James W, Smith, Daniel, Wilkinson, J Erby, Miller, Richard A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954939/
https://www.ncbi.nlm.nih.gov/pubmed/24245565
http://dx.doi.org/10.1111/acel.12170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954939/
https://www.ncbi.nlm.nih.gov/pubmed/24245565
http://dx.doi.org/10.1111/acel.12170

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