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Inflammatory cytokines promote growth of intestinal smooth muscle cells by induced expression of PDGF-Rβ

Thickening of the inflamed intestinal wall involves growth of smooth muscle cells (SMC), which contributes to stricture formation. Earlier, the growth factor platelet-derived growth factor (PDGF)-BB was identified as a key mitogen for SMC from the rat colon (CSMC), and CSMC growth in colitis was ass...

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Detalles Bibliográficos
Autores principales: Nair, Dileep G, Miller, Kurtis G, Lourenssen, Sandra R, Blennerhassett, Michael G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955151/
https://www.ncbi.nlm.nih.gov/pubmed/24417820
http://dx.doi.org/10.1111/jcmm.12193