Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf(V600E)::Pten−/− melanoma

Phosphoinositide-dependent kinase-1 (PDK-1) is a serine/threonine protein kinase that phosphorylates members of the conserved AGC kinase superfamily, including AKT and PKC, and is implicated in important cellular processes including survival, metabolism and tumorigenesis. In large cohorts of nevi an...

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Detalles Bibliográficos
Autores principales: Scortegagna, Marzia, Ruller, Chelsea, Feng, Yongmei, Lazova, Rossitza, Kluger, Harriet, Li, Jian-Liang, De, Surya K, Rickert, Robert, Pellecchia, Maurizio, Bosenberg, Marcus, Ronai, Ze’ev A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955742/
https://www.ncbi.nlm.nih.gov/pubmed/24037523
http://dx.doi.org/10.1038/onc.2013.383

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955742/
https://www.ncbi.nlm.nih.gov/pubmed/24037523
http://dx.doi.org/10.1038/onc.2013.383

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