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A 3D structural model and dynamics of hepatitis C virus NS3/4A protease (genotype 4a, strain ED43) suggest conformational instability of the catalytic triad: implications in catalysis and drug resistivity

Egypt has the highest prevalence of hepatitis C virus (HCV) infection worldwide with a frequency of 15%. More than 90% of these infections are due to genotype 4, and the subtype 4a (HCV-4a) predominates. Moreover, due to the increased mobility of people, HCV-4a has recently spread to several Europea...

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Detalles Bibliográficos
Autores principales: Rimmert, Bradley, Sabet, Salwa, Ackad, Edward, Yousef, Mohammad S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956140/
https://www.ncbi.nlm.nih.gov/pubmed/23768174
http://dx.doi.org/10.1080/07391102.2013.800001