Suppression of type 1 pilus assembly in uropathogenic Escherichia coli by chemical inhibition of subunit polymerization

OBJECTIVES: To identify and to characterize small-molecule inhibitors that target the subunit polymerization of the type 1 pilus assembly in uropathogenic Escherichia coli (UPEC). METHODS: Using an SDS–PAGE-based assay, in silico pre-filtered small-molecule compounds were screened for specific inhib...

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Detalles Bibliográficos
Autores principales: Lo, Alvin W. H., Van de Water, Karen, Gane, Paul J., Chan, A.W. Edith, Steadman, David, Stevens, Kiri, Selwood, David L., Waksman, Gabriel, Remaut, Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956373/
https://www.ncbi.nlm.nih.gov/pubmed/24324225
http://dx.doi.org/10.1093/jac/dkt467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956373/
https://www.ncbi.nlm.nih.gov/pubmed/24324225
http://dx.doi.org/10.1093/jac/dkt467

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