R-Loops in Proliferating Cells but Not in the Brain: Implications for AOA2 and Other Autosomal Recessive Ataxias

Disruption of the Setx gene, defective in ataxia oculomotor apraxia type 2 (AOA2) leads to the accumulation of DNA/RNA hybrids (R-loops), failure of meiotic recombination and infertility in mice. We report here the presence of R-loops in the testes from other autosomal recessive ataxia mouse models,...

Descripción completa

Detalles Bibliográficos
Autores principales: Yeo, Abrey J., Becherel, Olivier J., Luff, John E., Cullen, Jason K., Wongsurawat, Thidathip, Jenjaroenpoon, Piroon, Kuznetsov, Vladimir A., McKinnon, Peter J., Lavin, Martin F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956458/
https://www.ncbi.nlm.nih.gov/pubmed/24637776
http://dx.doi.org/10.1371/journal.pone.0090219

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956458/
https://www.ncbi.nlm.nih.gov/pubmed/24637776
http://dx.doi.org/10.1371/journal.pone.0090219

Ejemplares similares