Hematopoietic Properties of Granulocyte Colony-Stimulating Factor/Immunoglobulin (G-CSF/IgG-Fc) Fusion Proteins in Normal and Neutropenic Rodents

Previously we showed that granulocyte colony-stimulating factor (G-CSF) in vitro bioactivity is preserved when the protein is joined via a flexible 7 amino acid linker to an immunoglobulin-1 (IgG1)-Fc domain and that the G-CSF/IgG1-Fc fusion protein possessed a longer circulating half-life and impro...

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Detalles Bibliográficos
Autores principales: Cox, George N., Chlipala, Elizabeth A., Smith, Darin J., Carlson, Sharon J., Bell, Stacie J., Doherty, Daniel H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956888/
https://www.ncbi.nlm.nih.gov/pubmed/24637521
http://dx.doi.org/10.1371/journal.pone.0091990

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956888/
https://www.ncbi.nlm.nih.gov/pubmed/24637521
http://dx.doi.org/10.1371/journal.pone.0091990

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