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Hematopoietic Properties of Granulocyte Colony-Stimulating Factor/Immunoglobulin (G-CSF/IgG-Fc) Fusion Proteins in Normal and Neutropenic Rodents

Previously we showed that granulocyte colony-stimulating factor (G-CSF) in vitro bioactivity is preserved when the protein is joined via a flexible 7 amino acid linker to an immunoglobulin-1 (IgG1)-Fc domain and that the G-CSF/IgG1-Fc fusion protein possessed a longer circulating half-life and impro...

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Detalles Bibliográficos
Autores principales:	Cox, George N., Chlipala, Elizabeth A., Smith, Darin J., Carlson, Sharon J., Bell, Stacie J., Doherty, Daniel H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956888/ https://www.ncbi.nlm.nih.gov/pubmed/24637521 http://dx.doi.org/10.1371/journal.pone.0091990

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