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Why Is Mammalian Thioredoxin Reductase 1 So Dependent upon the Use of Selenium?

[Image: see text] Cytosolic thioredoxin reductase 1 (TR1) is the best characterized of the class of high-molecular weight (M(r)) thioredoxin reductases (TRs). TR1 is highly dependent upon the rare amino acid selenocysteine (Sec) for the reduction of thioredoxin (Trx) and a host of small molecule sub...

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Detalles Bibliográficos
Autores principales: Lothrop, Adam P., Snider, Gregg W., Ruggles, Erik L., Hondal, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957196/
https://www.ncbi.nlm.nih.gov/pubmed/24393022
http://dx.doi.org/10.1021/bi400651x

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